abstract：:Environmental or biomedical exposure to nanoparticles (NPs) can results in translocation and accumulation of NPs in the brain, which can lead to health-related problems. NPs have been shown to induce toxicity to neuronal cells through several direct mechanisms, but only a few studies have also explored the indirect ef...

journal_title：International journal of molecular sciences

authors： Lojk J,Babič L,Sušjan P,Bregar VB,Pavlin M,Hafner-Bratkovič I,Veranič P

更新日期：2020-09-24 00:00:00

abstract：:The use of mesenchymal stem cells (MSC) for the treatment of cutaneous wounds is currently of enormous interest. However, the broad translation of cell therapies into clinical use is hampered by their efficacy, safety, manufacturing and cost. MSCs release a broad repertoire of trophic factors and immunomodulatory cyto...

journal_title：International journal of molecular sciences

authors： Ahangar P,Mills SJ,Cowin AJ

更新日期：2020-09-24 00:00:00

abstract：:Brown adipose tissue (BAT) is an important target for obesity treatment and prevention. Soluble epoxide hydrolase (sEH) converts bioactive epoxy fatty acids (EpFAs) into less active diols. sEH inhibitors (sEHI) are beneficial in many chronic diseases by stabilizing EpFAs. However, roles of sEH and sEHI in brown adipog...

journal_title：International journal of molecular sciences

authors： Overby H,Yang Y,Xu X,Graham K,Hildreth K,Choi S,Wan D,Morisseau C,Zeldin DC,Hammock BD,Wang S,Bettaieb A,Zhao L

更新日期：2020-09-24 00:00:00

abstract：:The transmembrane protein cytochrome c oxidase (CcO) is the terminal oxidase in the respiratory chain of many aerobic organisms and catalyzes the reduction of dioxygen to water. This process maintains an electrochemical proton gradient across the membrane hosting the oxidase. CcO is a well-established model enzyme in ...

journal_title：International journal of molecular sciences

authors： Hugentobler KG,Heinrich D,Berg J,Heberle J,Brzezinski P,Schlesinger R,Block S

更新日期：2020-09-23 00:00:00

abstract：:The plasma membrane regulates biological processes such as ion transport, signal transduction, endocytosis, and cell differentiation/proliferation. To understand the functional characteristics and organ specificity of plasma membranes, plasma membrane protein fractions from rice root, etiolated leaf, green leaf, devel...

journal_title：International journal of molecular sciences

authors： Iwasaki Y,Itoh T,Hagi Y,Matsuta S,Nishiyama A,Chaya G,Kobayashi Y,Miura K,Komatsu S

更新日期：2020-09-23 00:00:00

abstract：:As a major site of glucose uptake following a meal, skeletal muscle has an important role in whole-body glucose metabolism. Evidence in humans and animal models of insulin resistance and type 2 diabetes suggests that alterations in mitochondrial characteristics accompany the development of skeletal muscle insulin resi...

journal_title：International journal of molecular sciences

authors： Genders AJ,Holloway GP,Bishop DJ

更新日期：2020-09-22 00:00:00

abstract：:Patients with advanced skeletal metastases arising from primary cancers including breast, lung, and prostate suffer from extreme pain, bone loss, and frequent fractures. While the importance of interactions between bone and tumors is well-established, our understanding of complex cell-cell and cell-microenvironment in...

journal_title：International journal of molecular sciences

authors： Dadwal UC,Merkel AR,Page JM,Kwakwa KA,Kessler M,Rhoades JA

更新日期：2020-09-21 00:00:00

abstract：:Circadian oscillations of mRNAs and proteins are the main features of circadian clock genes. Among them, Period1 (Per1) is a key component in negative-feedback regulation, which shows a robust diurnal oscillation and the importance of circadian rhythm and translational regulation of circadian clock genes has been reco...

journal_title：International journal of molecular sciences

authors： Kim W,Shin JC,Lee KH,Kim KT

更新日期：2020-09-21 00:00:00

abstract：:Phosphodiesterases (PDEs) are essential enzymes for the regulation of pathways mediated by cyclic adenosine monophosphate (cAMP). Secondary plant compounds like anthocyanins (ACs) can inhibit PDE activity and, consequently, may be beneficial for lipid metabolism. This study investigated 18 AC-rich juice extracts and p...

journal_title：International journal of molecular sciences

authors： Göttel C,Niesen S,Daub V,Werle T,Bakuradze T,Winterhalter P,Richling E

更新日期：2020-09-21 00:00:00

abstract：:Due to their large spectrum of bioactive properties, much attention has recently been drawn to phlorotannins-i.e., phenolic compounds characteristic from brown macroalgae. This study aimed to evaluate the antioxidant and anti-inflammatory properties of F. vesiculosus phlorotannin extracts and purified fractions. Overa...

journal_title：International journal of molecular sciences

authors： Catarino MD,Silva A,Cruz MT,Mateus N,Silva AMS,Cardoso SM

更新日期：2020-09-20 00:00:00

abstract：:Down syndrome (DS), the most common cause of intellectual disability of genetic origin, is characterized by alterations in central nervous system morphology and function that appear from early prenatal stages. However, by the fourth decade of life, all individuals with DS develop neuropathology identical to that found...

journal_title：International journal of molecular sciences

authors： Martínez-Cué C,Rueda N

更新日期：2020-09-20 00:00:00

abstract：:The worldwide increase in grapevine trunk diseases, mainly esca, represents a major threat for vineyard sustainability. Biocontrol of a pioneer fungus of esca, Phaeomoniella chlamydospora, was investigated here by deciphering the tripartite interaction between this trunk-esca pathogen, grapevine and the biocontrol-oom...

journal_title：International journal of molecular sciences

authors： Yacoub A,Magnin N,Gerbore J,Haidar R,Bruez E,Compant S,Guyoneaud R,Rey P

更新日期：2020-09-19 00:00:00

abstract：:Osteosarcoma is the most common primary malignant bone tumour in children and adolescents. Due to micrometastatic spread, radical surgery alone rarely results in cure. Introduction of combination chemotherapy in the 1970s, however, dramatically increased overall survival rates from 20% to approximately 70%. Unfortunat...

journal_title：International journal of molecular sciences

authors： Lilienthal I,Herold N

更新日期：2020-09-19 00:00:00

abstract：:Type 2 diabetes mellitus (T2D) is a chronic metabolic disease resulting from insulin resistance and progressively reduced insulin secretion, which leads to impaired glucose utilization, dyslipidemia and hyperinsulinemia and progressive pancreatic beta cell dysfunction. The incidence of type 2 diabetes mellitus is incr...

journal_title：International journal of molecular sciences

authors： Nasykhova YA,Tonyan ZN,Mikhailova AA,Danilova MM,Glotov AS

更新日期：2020-09-18 00:00:00

abstract：:CD4+T-lymphocytes are relevant in the pathogenesis of rheumatoid arthritis (RA), however, their potential involvement in early RA remains elusive. Methotrexate (MTX) is a commonly used disease-modifying antirheumatic drug (DMARD), but its mechanism has not been fully established. In 47 new-onset DMARD-naïve RA patient...

journal_title：International journal of molecular sciences

authors： Monserrat Sanz J,Bohórquez C,Gómez AM,Movasat A,Pérez A,Ruíz L,Diaz D,Sánchez AI,Albarrán F,Sanz I,Álvarez-Mon M

更新日期：2020-09-18 00:00:00

abstract：:Several research disciplines require fast, reliable and highly automated determination of pharmaceutically active compounds and their enantiomers in complex biological matrices. To address some of the challenges of Capillary Electrophoresis (CE), such as low concentration sensitivity and performance degradation linked...

journal_title：International journal of molecular sciences

authors： Masár M,Hradski J,Schmid MG,Szucs R

更新日期：2020-09-18 00:00:00

abstract：:Sequence-defined recombinant antibodies (rAbs) have emerged as alternatives to hybridoma-secreted monoclonal antibodies (mAbs) for performing immunoassays. However, the polyploidy nature of hybridomas often leads to the coexistence of aberrant or non-specific functional variable region (VR) gene transcripts, which com...

journal_title：International journal of molecular sciences

authors： Liu P,Guo Y,Jiao S,Chang Y,Liu Y,Zou R,Liu Y,Chen M,Guo Y,Zhu G

更新日期：2020-09-18 00:00:00

abstract：:Epidemiological studies on workers employed at the Mayak plutonium enrichment plant have demonstrated an association between external gamma ray exposure and an elevated risk of ischemic heart disease (IHD). In a previous study using fresh-frozen post mortem samples of the cardiac left ventricle of Mayak workers and no...

journal_title：International journal of molecular sciences

authors： Azimzadeh O,Azizova T,Merl-Pham J,Blutke A,Moseeva M,Zubkova O,Anastasov N,Feuchtinger A,Hauck SM,Atkinson MJ,Tapio S

更新日期：2020-09-17 00:00:00

abstract：:The paper studies the combined effects of beta-emitting radionuclide tritium and Humic Substances (HS) on the marine unicellular microorganism-luminous bacteria-under conditions of low-dose radiation exposures (<0.04 Gy). Tritium was used as a component of tritiated water. Bacterial luminescence intensity was consider...

journal_title：International journal of molecular sciences

authors： Rozhko TV,Kolesnik OV,Badun GA,Stom DI,Kudryasheva NS

更新日期：2020-09-16 00:00:00

abstract：:Neuroblastoma is the most common extracranial solid tumor in childhood. The different treatments available for neuroblastoma are challenged by high rates of resistance, recurrence, and progression, most notably in advanced cases and highly malignant tumors. Therefore, the development of more targeted therapies, which ...

journal_title：International journal of molecular sciences

authors： Gurunathan S,Jeyaraj M,Kang MH,Kim JH

更新日期：2020-09-16 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a leading cause of cancer-related morbidity and mortality worldwide. Most patients are diagnosed with advanced disease, limiting their options for treatment. While current treatments are adequate for lower staged disease, available systemic treatments are limited, with marginal benefi...

journal_title：International journal of molecular sciences

authors： Patel K,Lamm R,Altshuler P,Dang H,Shah AP

更新日期：2020-09-15 00:00:00

abstract：:Microgravity is known to affect the organization of the cytoskeleton, cell and nuclear morphology and to elicit differential expression of genes associated with the cytoskeleton, focal adhesions and the extracellular matrix. Although the nucleus is mechanically connected to the cytoskeleton through the Linker of Nucle...

journal_title：International journal of molecular sciences

authors： Neelam S,Richardson B,Barker R,Udave C,Gilroy S,Cameron MJ,Levine HG,Zhang Y

更新日期：2020-09-15 00:00:00

abstract：:Tendinopathy is the term used to refer to tendon disorders. Spontaneous adult tendon healing results in scar tissue formation and fibrosis with suboptimal biomechanical properties, often resulting in poor and painful mobility. The biomechanical properties of the tissue are negatively affected. Adult tendons have a lim...

journal_title：International journal of molecular sciences

authors： Citeroni MR,Ciardulli MC,Russo V,Della Porta G,Mauro A,El Khatib M,Di Mattia M,Galesso D,Barbera C,Forsyth NR,Maffulli N,Barboni B

更新日期：2020-09-14 00:00:00

abstract：:Spinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine expansion in Ataxin-2 (ATXN2). This factor binds RNA/proteins to modify metabolism after stress, and to control calcium (Ca2+) homeostasis after stimuli. Cerebellar ataxias and corticospinal motor neuron degeneration are determined by gain/loss in ATXN2 f...

journal_title：International journal of molecular sciences

authors： Arsović A,Halbach MV,Canet-Pons J,Esen-Sehir D,Döring C,Freudenberg F,Czechowska N,Seidel K,Baader SL,Gispert S,Sen NE,Auburger G

更新日期：2020-09-12 00:00:00

abstract：:Protein-bound uremic toxins, such as p-cresol sulfate (PCS), can be accumulated with declined renal function and aging and is closely linked with central nervous system (CNS) diseases. In the periphery, PCS has effects on oxidative stress and inflammation. Since oxidative stress and inflammation have substantial roles...

journal_title：International journal of molecular sciences

authors： Sun CY,Li JR,Wang YY,Lin SY,Ou YC,Lin CJ,Wang JD,Liao SL,Chen CJ

更新日期：2020-09-12 00:00:00

abstract：:Sirtuins (SIRTs) are class III histone deacetylases (HDACs) that play important roles in aging and a wide range of cellular functions. Sirtuins are crucial to numerous biological processes, including proliferation, DNA repair, mitochondrial energy homeostasis, and antioxidant activity. Mammals have seven different sir...

journal_title：International journal of molecular sciences

authors： Hong YA,Kim JE,Jo M,Ko GJ

更新日期：2020-09-12 00:00:00

abstract：BACKGROUND:Gastritis is a prevalent disease and commonly classified into autoimmune (A), bacterial (B), and chemical (C) type gastritis. While the former two subtypes are associated with an increased risk of developing gastric intestinal adenocarcinoma, the latter subtype is not. In this study, we evaluated the capabil...

journal_title：International journal of molecular sciences

authors： Steinbuss G,Kriegsmann K,Kriegsmann M

更新日期：2020-09-11 00:00:00

abstract：:Collagen prolyl 4-hydroxylase 1 (C-P4H1) is an α-ketoglutarate (α-KG)-dependent dioxygenase that catalyzes 4-hydroxylation of proline on collagen. C-P4H1-induced prolyl hydroxylation is required for proper collagen deposition and cancer metastasis. Therefore, targeting C-P4H1 is considered a potential therapeutic stra...

journal_title：International journal of molecular sciences

authors： Wang S,Lee KH,Araujo NV,Zhan CG,Rangnekar VM,Xu R

更新日期：2020-09-10 00:00:00

abstract：:A considerable number of drugs and/or their metabolites are excreted by the kidneys through glomerular filtration and active renal tubule secretion via transporter proteins. Uptake transporters in the proximal tubule are part of the solute carrier (SLC) superfamily, and include the organic cation transporters (OCTs). ...

journal_title：International journal of molecular sciences

authors： Zazuli Z,Duin NJCB,Jansen K,Vijverberg SJH,Maitland-van der Zee AH,Masereeuw R

更新日期：2020-09-10 00:00:00

abstract：:Phototropin2 (phot2) is a blue-light (BL) receptor protein that regulates the BL-dependent activities of plants for efficient photosynthesis. Phot2 is composed of two light-oxygen-voltage sensing domains (LOV1 and LOV2) to absorb BL, and a kinase domain. Photo-activated LOV domains, especially LOV2, play a major role ...

journal_title：International journal of molecular sciences

authors： Nakasako M,Oide M,Takayama Y,Oroguchi T,Okajima K

更新日期：2020-09-10 00:00:00

abstract：:Squamous cell carcinoma (SCC) is the second commonest type of skin cancer, and SCCs make up about 90% of head and neck cancers (HNSCCs). HNSCCs harbor two frequent molecular alterations, namely, gain-of-function alterations of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and loss-of-...

journal_title：International journal of molecular sciences

authors： Chen SMY,Li B,Nicklawsky AG,Krinsky AL,Brunetti T,Woolaver RA,Wang X,Chen Z,Young CD,Gao D,Wang XJ,Wang JH

更新日期：2020-09-09 00:00:00

abstract：:Leuconostoc mesenteroides DRP105 isolated from Chinese sauerkraut juice is an intensive producer of dextran. We report the complete genome sequence of Leu. mesenteroides DRP105. This strain contains a dextransucrase gene (dsr) involved in the production of dextran, possibly composed of glucose monomers. To explore the...

journal_title：International journal of molecular sciences

authors： Du R,Zhou Z,Han Y

更新日期：2020-09-09 00:00:00

abstract：:STIM1 is an endoplasmic reticulum (ER) protein that modulates the activity of a number of Ca2+ transport systems. By direct physical interaction with ORAI1, a plasma membrane Ca2+ channel, STIM1 activates the ICRAC current, whereas the binding with the voltage-operated Ca2+ channel CaV1.2 inhibits the current through ...

journal_title：International journal of molecular sciences

authors： Pascual-Caro C,Orantos-Aguilera Y,Sanchez-Lopez I,de Juan-Sanz J,Parys JB,Area-Gomez E,Pozo-Guisado E,Martin-Romero FJ

更新日期：2020-09-09 00:00:00

abstract：:Atherosclerosis is an arterial inflammatory disease. The circulating level of the C-C chemokine ligand (CCL4) is increased in atherosclerotic patients. This study aimed to investigate whether CCL4 inhibition could retard the progression of atherosclerosis. In ApoE knockout mice, CCL4 antibody treatment reduced circula...

journal_title：International journal of molecular sciences

authors： Chang TT,Yang HY,Chen C,Chen JW

更新日期：2020-09-08 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) are able to promote the survival of multiple neuronal populations in the body and, therefore, hold considerable promise for disease-modifying treatments of diseases and conditions caused by neurodegeneration. Available data reveal the potential o...

journal_title：International journal of molecular sciences

authors： Sidorova YA,Saarma M

更新日期：2020-09-08 00:00:00

abstract：:Sarcopenia is primarily characterized by skeletal muscle disturbances such as loss of muscle mass, quality, strength, and physical performance. It is commonly seen in elderly patients with chronic diseases. The prevalence of sarcopenia in chronic heart failure (HF) patients amounts to up to 20% and may progress into c...

journal_title：International journal of molecular sciences

authors： Lena A,Anker MS,Springer J

更新日期：2020-09-08 00:00:00

abstract：:Understanding disease pathology often does not require an overall proteomic analysis of clinical samples but rather the analysis of different, often rare, subpopulations of cells in a heterogeneous mixture of cell types. For the isolation of pre-specified cellular subtypes, fluorescence activated cell sorting (FACS) i...

journal_title：International journal of molecular sciences

authors： Maes E,Cools N,Willems H,Baggerman G

更新日期：2020-09-08 00:00:00

abstract：:Absent in melanoma 2 (AIM2) is a cytosolic receptor that recognizes double-stranded DNA (dsDNA) and triggers the activation of the inflammasome cascade. Activation of the inflammasome results in the maturation of inflammatory cytokines, such as interleukin (IL)-1 β and IL-18, and a form of cell death known as pyroptos...

journal_title：International journal of molecular sciences

authors： Lozano-Ruiz B,González-Navajas JM

更新日期：2020-09-07 00:00:00

abstract：:The establishment of a proangiogenic phenotype and epithelial-to-mesenchymal transition (EMT) are considered as critical events that promote the induction of invasive growth in epithelial tumors, and stimulation of lymphangiogenesis is believed to confer the capacity for early dissemination to cancer cells. Recent res...

journal_title：International journal of molecular sciences

authors： Kurmyshkina O,Kovchur P,Schegoleva L,Volkova T

更新日期：2020-09-06 00:00:00

abstract：:Compared to other mammalian species, porcine oocytes and embryos are characterized by large amounts of lipids stored mainly in the form of droplets in the cytoplasm. The amount and the morphology of lipid droplets (LD) change throughout the preimplantation development, however, relatively little is known about express...

journal_title：International journal of molecular sciences

authors： Kajdasz A,Warzych E,Derebecka N,Madeja ZE,Lechniak D,Wesoly J,Pawlak P

更新日期：2020-09-05 00:00:00